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. 2021 Mar 10;12:626621. doi: 10.3389/fphar.2021.626621

FIGURE 1.

FIGURE 1

Effect of catalpol on structural parameters of trabecular bone of diabetic osteoporosis mice. Representative 3D reconstructed images analyzed by micro-CT (A, B, C, D). (A) Control group; (B) model group (diabetic osteoporosis group); (C) 30 mg/kg (diabetic osteoporosis group with 30 mg/kg catalpol); (D) 90 mg/kg (diabetic osteoporosis group with 90 mg/kg catalpol). The reconstructed images suggested that catalpol could observably inhibit the trabecular bone mass loss and significantly attenuated the degeneration of trabecular bone microarchitecture. (E) The effect of catalpol on trabecular BMD of the femoral bone. The trabecular BMD of the femoral bone of the model group significantly decreased (p < 0.05), and catalpol (90 mg/kg catalpol) inhibited this effect. The effect of catalpol on BMD BVF, BS/BV, Tb.Th, Tb.N, and Tb. Sp of the mice femur mice in four groups. (F) BVF; (G) BS/BV(%); (H) trabecular number (N/mm); (I) trabecular spacing (μm); (J) trabecular thickness (μm). The data were expressed as the mean ± SD. **p < 0.01 and *p < 0.05 vs. control and # p < 0.05 vs. model.