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. 2021 Mar 10;12:626621. doi: 10.3389/fphar.2021.626621

FIGURE 2.

FIGURE 2

Effect of catalpol on bone formation and bone resorption. (A) Representative images of ALP staining. Compared with control group, the levels of ALP in the femur, thoracic vertebra, and lumbar vertebra of diabetic mice were reduced significantly, and catalpol can reverse this effect. (B) Serum TRACP-5b levels of mice in four groups assayed by ELISA; there is no significant difference among groups. (C) Serum ALP levels of mice in four groups assayed by ELISA. Serum ALP levels of diabetic mice in the model group were decreased significantly, and administration of catalpol (90 mg/kg) significantly improved the ALP levels. (D) Serum osteocalcin levels of mice in four groups assayed by ELISA. In the model group, osteocalcin levels were decreased significantly, and administration of catalpol can reverse this decrease. The data were expressed as the mean ± SD. ** p < 0.01 vs. control and ## p < 0.01 and # p < 0.05 vs. model.