Table 1.
Select rapid phenotypic AST methods that are approved for testing positive blood cultures.
| Test | AST technology | TTR | Regulatory status | References |
|---|---|---|---|---|
| PhenoTest BC (Accelerate Diagnostics) | Time-lapse imaging of bacterial cells under dark-field microscopy. Morphological and kinetic changes analyzed. | 7 h | US FDA cleared, CE-IVD | (46) |
| Alfred (AliFAX) | Light scattering to detect bacterial growth in liquid culture broth. | 3–5 h | CE-IVD | (47) |
| dRAST (QuantaMatrix) | Time-lapse imaging of bacterial cells on micropatterned plastic microchips. | 6 h | CE-IVD | (48) |
| Reveal AST (Specific Diagnostics) | Sensor array for volatile organic compounds emitted during microorganism growth. | 4.5 h | CE-IVD | 1 |
| ASTar (Q-linea) | Time-lapse imaging of bacterial growth in broth. | 3–6 h | CE-IVD | 2 |
| Fastinov | Flow cytometry applying fluorescent dyes that reveal cell damage during treatment. | 80 min | CE-IVD | 3 |
| LifeScale (Affinity Biosensors) | Mass measurement using a microcantilever. | 4 h | CE-IVD | 4 |
AST, antimicrobial susceptibility testing; TTR, time to result.
1
https://specificdx.com/reveal-ast (accessed November 30, 2020).
2
https://www.qlinea.com/our-products/astar/astar-instrument/ (accessed November 30, 2020).
3
http://www.fastinov.com/ (accessed November 30, 2020).
4
http://www.lifescaleinstruments.com/Products/Clinical (accessed November 30, 2020).