Table 1.
TGFβ receptors and SMADs’
| LIGAND | Type II receptor | Type I receptor | Type III receptor | SMAD |
|---|---|---|---|---|
| TGFβ1 | TGFβRII | ACVRL1/ALK1, ALK5, ACTRIA(ALK2) | TGFβRIII/betaglycan, Cripto | 1,2,3,5,8 |
| TGFβ2 | TGFβRII | ACTRIA(ALK2), ALK5/ TGFβRI | TGFβRIII/betaglycan | 1,2,3,5,8 |
| TGFβ3 | TGFβRII | ACVRL1/ALK1, ACTR-IA(ALK2), ALK5/ TGFβRI | TGFβRIII/betaglycan | 1,2,3,5,8 |
| BMP2/4 | BMPRII, ACTRII, ACTRIIB | ACTR-IA(ALK2), BMPRIA (ALK3), BMPRIB (ALK6) |
TGFβRIII/betaglycan, END/Endoglin, RGMB/Dragon |
1,5,8 |
| BMP5/6/7 | ACTRII, ACTRIIB, BMPRII | ACVR1 (ALK2), BMPRIA (ALK3), BMPRIB (ALK6) | TGFβRIII/betaglycan | 1,5,8 |
| BMP9/GDF2 | BMPRII | ACVRL1(ALK1), ACTR-IA(ALK2), BMPR-IA(ALK3) | END/Endoglin | 1,5,8 |
| BMP10 | BMPRII | ACVRL1(ALK1) | ||
| Activin A/B | ACTRII, ACTRIIB | ACTRIA(ALK2), ACTR-IB(ALK4) | END/Endoglin | 2,3 |
| Inhibin A/B | ACTRII, ACTRIIB | ACTRIB(ALK4), ACVRL1 | TGFβRIII/betaglycan, END/Endoglin | |
| GDF5 | BMPRII, ACT\\RII, ACTRIIB | BMPR1B (ALK6) | TGFβRIII/betaglycan | 1,5,8 |
| GDF1 | ACTRII | ACTRIB(ALK4) | Cripto | 2,3 |
| GDF11 | ACTRII, ACTRIIB | ACTRIB(ALK4) | N. D | 2,3 |
| MIS | MISRII | BMPRIA(ALK3), ACTRIA(ALK2), BMPRIB (ALK6) | N. D | 1,5,8 |
| Nodal | ACTRII, ACTRIIB | ACTRIB(ALK4), ALK7 | Cripto | 2,3 |
| GDF9 | ACTRII, BMPRII | BMPRIB (ALK6) | N. D | |
| GDF8 | ACTRII, ACTRIIB | ActRIB (ALK4), ALK5 | N. D | 2,3 |
| GDF6 | BMPRII | BMPRIA (ALK3), BMPRIB (ALK6) | RGMB/Dragon | 1/5/8 |