Table 3.
Small-molecule drugs delivered by polymeric nanocarriers: conditions used for the fractionation and quantification of the associated drug
| Drug | Nanocarrier | Eluent | Detector | Ref |
|---|---|---|---|---|
| 212Pb-DTPA | DSPC/cholesterol/DSPE-DTPA liposomes | 5 mM NaCl + 0.001% Tween-20 | Online γ-ray detector | [138] |
| Aluminum chloride phthalocyanine | PLA nanocapsules, PEG-PLA nanocapsules, PLA-chitosan nanocapsules | MilliQ water | Offline HPLC-FLD | [131] |
| PEG-P(LA-co-BGE) nanospheres | 10 mM NaCl | Offline HPLC-FLD | [132] | |
| Amphotericin B | Commercial liposomal formulation | 0.5 mM NaCl | Offline HPLC–UV/VIS | [146] |
| Clofazimine | SBE-β-CD oligomers | MilliQ water | Online DAD UV/Vis | [134] |
| Curcumin | PMOXA-PDMS-PMOXA polymersomes | 10 mM PB (pH 7.4) | Online FLD | [143] |
| Star polymer micelles | 1 × PBS (pH 7.4) | Online UV/VIS-FLD | [194] | |
| Daunorubicin, docetaxel, doxorubicin, SN-38 | Commercial micellar and liposomal formulations | 1 × PBS | Offline HPLC–UV/VIS | [149] |
| Doxorubicin | Commercial liposomal formulation | 100 mM NaCl | Offline HPLC–DAD | [148] |
| IR-780 Iodide | PEG-PLA nanocapsules | 10 mM NaCl | Online FLD | [91] |
| Pheophorbide | PEO-b-PCL micelles and vesicles | 0.02% NaN3 | Online UV/Vis | [133] |
| p-THPP | Liposomes (E80S egg phospholipids) | 10 mM TRIS (pH 7.4) + 0.02% NaN3 | Online UV/Vis, offline HPLC–UV/Vis | [129] |
| Rose Bengal | Hyper-branched polymer decorated with maltose moieties | 0.02% NaN3 | Online UV/Vis (on the waste line) | [150] |
| Temoporfin (radioactively labeled) | POPC/POPG and DPPC/DPPG liposomes | 0.02% NaN3 | Offline scintillation counter | [145] |
DPPC 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine, DPPG 1,2-dipalmitoyl-sn-glycero-3-phosphatidylglycerol, DSPC 1,2-distearoyl-sn-glycero-3-phosphocholine, DTPA diethylenetriaminepentaacetic acid, PEG polyethylene glycol, PEG-P(LA-co-BGE) polyethylene glycol-block-poly-(D,L-lactide-co-benzyl glycidyl ether), PEO-b-PCL poly(ethyleneoxide-b-ε-caprolactone), PLA polylactic acid, PMOXA-PDMS-PMOXA poly(2-methyl-2-oxazoline)-block-poly-(dimethysiloxane)-block-poly(2-methyl-2-oxazoline), POPC 1-palmitoyl-2-oleoylphosphatidylcholine, POPG 1-palmitoyl-2-oleoyl-sn-glycero- 3-phosphatidylglycerol, SBE-β-CD sulfobutylether-β-ciclodextrins