Table 4.

Proteins, peptides and nucleic acids delivered by polymeric nanocarriers: conditions used for the fractionation. All drugs were quantified by online UV/Vis spectrometry

	Drug	Nanocarrier	Eluent	Ref
Antibodies	Human IgG1-R, IgG1-T, murine IgG2a-A20 Id	Keyhole limpet hemocyanin conjugates	1 × PBS (pH 7.2) + 0.02% NaN3	[195]
Other proteins/peptides	Esterase (porcine liver), myoglobin (equine skeletal muscle)	PEG-DEAEMA-DMIBMA polymersomes	1 × PBS + 0.02% NaN3	[144]
	Peptide PCS5	Chitosan/dextran sulfate nanoparticles	SDS 0.1%	[38]
	Several proteins	Polyphosphazene (PCPP and PCEP) complexes	1 × PBS (pH 7.4)	[105]
	Lysozyme	Spermine-crosslinked polyphosphazene (PCPP and PCPP-PEG) nanoparticles	1 × PBS (pH 7.4)	[196]
	Nerve growth factor	PMOXA − PDMS − PMOXA polymersomes	10 mM PB (pH 7.4)	[143]
Nucleic acids and nucleosides	Fludarabine-5′-triphosphate, clofarabine-5′-triphosphate	Maltose-modified poly(propyleneimine) dendrimers	10 mM HEPES (pH 5.8 or 7.4)	[173]
	pGreen Lantern-1 plasmid	DOTAP/DOPE liposomes	89 mM Tris-borate (pH 8.59)	[197]
	Linear salmon sperm DNA, pEGFP-N1 plasmid	Hybrid micelles (PS-b-PQ2VP/oleic acid-stabilized iron oxide nanoparticles)	0.02% NaN3	[198]

DOPE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOTAP 1,2-dioleoyl-3-trimethylammonium propane, PCEP poly[di(carboxylatoethylphenoxy)phosphazene], PCPP poly[di(carboxylatophenoxy)phosphazene, PCPP-PEG poly[di(carboxylatophenoxy)phosphazene-block-polyethylene glycol, PEG-DEAEMA-DMIBMA polyethylene glycol-block-diethylaminoethyl-methacrylate-block-4-(3,4-dimethylmaleicimido)butyl methacrylate, PS-b-PQ2VP polystyrene-blcok-poly(quaternized 2-vinylpyridine)