Table 1.
Significantly enriched miRNA seed variants in the comparison of patient cohort with gnomAD NFE population.
| miRNA | Chr | Start | End | Ref | Alt | dbSNP150 | AF_Patient1 | AF_gnomAD NFE1 | pVal2 | FDR3 |
|---|---|---|---|---|---|---|---|---|---|---|
| hsa-mir-4472-2-5p | 12 | 116866112 | 116866114 | CA | - | rs202127912 | 0.23 | 1.60E-02 | 2.6E-54 | 1.5E-51 |
| hsa-mir-8078–3p | 18 | 112284 | 112285 | G | C | 0 | 0.17 | 3.90E-02 | 2.2E-16 | 6.1E-15 |
| hsa-mir-8078–3p | 18 | 112286 | 112287 | C | A | rs775697263 | 0.15 | 3.50E-02 | 4.3E-16 | 1.2E-14 |
| hsa-mir-8078–3p | 18 | 112281 | 112282 | C | A | 0 | 0.04 | 1.00E-03 | 5.4E-13 | 1.2E-11 |
| hsa-mir-1273a-3p | 8 | 101036233 | 101036234 | G | A | rs932668866 | 0.01 | 1.34E-04 | 1.2E-04 | 1.5E-03 |
| hsa-mir-6859-1-3p | 1 | 17384 | 17385 | G | A | rs201535981 | 0.25 | 1.60E-01 | 6.1E-04 | 6.8E-03 |
| hsa-mir-1273d-5p | 1 | 10287790 | 10287791 | A | G | 0 | 0.01 | 6.74E-05 | 1.6E-03 | 1.6E-02 |
| hsa-mir-302c-3p | 4 | 113569539 | 113569543 | ACTT | - | rs199971565 | 0.06 | 3.00E-02 | 5.1E-03 | 4.4E-02 |
1
Allele Frequency of the patient and gnomAD NFE group, respectively
2
Raw p-value from Fisher’s Exact test
3
Benjamini-Hochberg adjusted p-value