Table 3.

B Lymphocytes subsets.

	Controls n = 125	GLILD n = 47	uILD n = 26	p value	p value	p value
	Median (IQR)	Median (IQR)	Median (IQR)	(GLILD vs. ctrls)	(uILD vs. GLILD)	(uILD vs. ctrls)
Lymphocytes %	29.0 (22.3–37.6)	27.8 (21.8–39.4)	29.0 (26.0–35.0)	0.87	0.54	0.93
Lymphocytes count	2.05 (1.4–2.6)	1.54 (0.99–2.57)	1.87 (1.10–2.30)	0.02	0.67	0.44
CD19+ B cells (% of lymphocytes)	7.0 (3.0–12.6)	6.0 (3.0–10.0)	4.0 (2.0–11–0)	0.91	0.17	0.32
Naïve (% of B cells)	72 (56.6–86.0)	81.2 (54.2–88.2)	75.9 (52.0–81.2)	0.48	0.10	0.63
Switched memory (% of B cells)	2.5 (1.0–6.6)	1.3 (0.1–5.0)	3.0 (0.6–5.9)	0.043	0.20	0.71
Marginal zone (% of B cells)	11.1 (2.4–24.6)	3.5 (1.3–11.0)	8.0 (5.0–16.7)	0.043	0.27	0.48
Transitional (% of B cells)	1.0 (0.2–2.5)	0.6 (0.0–4.0)	2.7 (0.6–7.5)	0.94	0.14	0.09
Plasmablasts (% of B cells)	0.1 (0.0–0.8)	0.3 (0.0–1.1)	0.1 (0.0–1.2)	0.11	0.47	0.66
CD21lo (% of B cells)	3.9 (1.9–7.7)	14.2 (10.1–30.0)	6.0 (2.8–29.3)	<0.0001	0.24	0.051

B cells sub-populations are identified according to EUROclass study: Naïve IgD⁺IgM⁺CD27⁻; Switched memory IgD⁻IgM⁻CD27⁺; Marginal zone IgD⁺IgM⁺CD27⁺; Transitional CD38⁺⁺IgM^high; Activated CD21^lowCD38^low; Plasmablasts CD38⁺⁺⁺IgM⁻(25).