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. 2021 Mar 10;12:651619. doi: 10.3389/fimmu.2021.651619

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Copyright © 2021 Meyer, Michalik, Holtfreter, Weiss, Friedrich, Völzke, Kocher, Kohler, Schmidt, Bröker and Völker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum IgA titers against S. aureus are highly variable with very large differences among the 996 tested individuals as well as the 79 included staphylococcal antigens. (A) The calculated IgA response values of all 996 individuals (y-axis) were plotted against the 79 antigens (x-axis) on a log10-transformed scale. Phenotypic information on the individuals was included in the additional columns on the right of the heatmap including carriage status, sex, age, BMI, allergy, and smoking. (B) Overview of overall high (orange) and overall low (petrol) responders, the calculated response is plotted as boxplot for all antigens and individuals, ordered with increasing median responses. (C) Ranking of the antigens according to IgA responses from all individuals.