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. 2021 Mar 10;12:610164. doi: 10.3389/fphar.2021.610164

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Copyright © 2021 Hering, Luettig, Jebautzke, Schulzke and Rosenthal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of punicalagin, ellagic acid and urolithin A on transepithelial resistance (TER) in Caco-2 monolayers. Changes in TER from initial values were measured at 24 h after challenging monolayers with different doses of (A) punicallagin (Puni) (p*<0.05, ***p < 0.001 vs. control; ^# p < 0.05 50 vs. 150 μM; n = 3–12) (B) urolithin A (UroA) (***p < 0.001 vs. control; n = 3–12) or (C) ellagic acid (EA) (p*<0.05, **p < 0.01, ***p < 0.001 vs. control; n = 6–15) (D) Comparison of the most effective dose of each compound on TER at 24 h after challenging (***p < 0.001 vs. control;^### p < 0.001 vs. ellagic acid; n = 6–9).