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. 2021 Mar 10;12:610164. doi: 10.3389/fphar.2021.610164

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Copyright © 2021 Hering, Luettig, Jebautzke, Schulzke and Rosenthal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ellagic acid reduces protein expression of TJ proteins claudin-4, -7 and -15 in Caco-2 monolayers (A) Representative Western blots and densitometry show reduced expression of claudin-4, -7 and -15 in ellagic acid (EA)-challenged monolayers (p***<0.001 vs. control; n = 7–10) (B) Representative micrographs of immunofluorescence staining show claudin-4, claudin-7 and claudin-15 in control and elllagic acid-challenged monolayers (green). ZO-1 served as TJ marker (red), nuclei were DAPI stained (blue) (n = 3 each) (C) Representative freeze-fracture EM micrographs of control and ellagic acid-challenged monolayers show no differences in TJ ultra-structure.