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. 2021 Mar 10;12:610164. doi: 10.3389/fphar.2021.610164

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Copyright © 2021 Hering, Luettig, Jebautzke, Schulzke and Rosenthal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Urolithin A on TNFα-caused claudin-1 delocalization in HT-29/B6 monolayers. Localization of claudin-1 was studied by confocal laser scanning microscopy in (A) control (B) TNFα (C) urolithin A (UroA) +TNFα and (D) urolithin A-challenged monolayers. Merging of claudin-1 (green) with the TJ marker protein ZO-1 (red) was assessed by z-stack imaging, nuclei are DAPI stained (blue). TNFα caused delocalization of claudin-1 (indicated by white arrows in (B)), while parallel Urolithin A treatment enhanced claudin-1-ZO-1 merging (indicated by white arrows in (C)). Bars indicate 5 µm.