Figure 4. Chlorzoxazone-baclofen improves cerebellar motor impairment in Atxn1^154Q/2Q mice.

Atxn1^154Q/2Q mice and wild-type littermate controls were treated with chlorzoxazone-baclofen in water bottles starting at 13 weeks of age. (A) Grip strength was measured in Atxn1^154Q/2Q mice and wild-type littermate controls at 14 weeks of age using a hanging wire task. (B) The time to fall off of a rotarod at constant speed was recorded for Atxn1^154Q/2Q mice and wild-type littermate controls at 14 weeks of age. (C) Similar to (A), at 20 weeks of age. (D) Similar to (B), at 20 weeks of age. * denotes p<0.05; ** denotes p<0.01; *** denotes p<0.001; ns denotes p>0.05. Two-way repeated measures ANOVA with Holm-Sidak correction for multiple comparisons (A, C); one-way ANOVA with Holm-Sidak correction for multiple comparisons (B, D).