Table 3.
Risk factors of PHLF in patients with HCC.
| Variables | Levels | Univariate logistic regression | Multivariate logistic regression | ||||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | Statistics | P-value | OR (95%CI) | Statistics | P-value | ||
| Age | / | 1.010 (0.977–1.045) | 0.599 | 0.549 | |||
| Gender | Male | 1 | −1.164 | 0.244 | |||
| Female | 0.501 (0.157–1.604) | ||||||
| Height | / | 1.056 (0.993–1.124) | 1.724 | 0.085 | 0.993 (0.916–1.076) | −0.167 | 0.867 |
| Weight | / | 1.015 (0.978–1.054) | 0.808 | 0.419 | |||
| BMI | / | 1.009 (0.894–1.138) | 0.142 | 0.887 | |||
| DM | Absent | 1 | −0.033 | 0.974 | |||
| Present | 0.980 (0.296–3.248) | ||||||
| Alcohol consumption | Absent | 1 | −0.479 | 0.632 | |||
| Present | 0.818 (0.359–1.862) | ||||||
| NAFLD | Absent | 1 | −0.013 | 0.990 | |||
| Present | 0.982 (0.060–16.099) | ||||||
| VH | Absent | 1 | 1.911 | 0.056 | 1 | −1.683 | 0.092 |
| HBV | 2.625 (0.976–7.062) | 0.017 (0.000–1.950) | |||||
| BCLC stage | 0~A | 1 | / | / | |||
| B | 1.369 (0.487–3.846) | 0.596 | 0.551 | ||||
| C | 1.244 (0.540–2.867) | 0.607 | 0.607 | ||||
| MELD score | / | 1.252 (1.076–1.456) | 2.911 | 0.004 | 2.062 (0.966–4.400) | 1.871 | 0.061 |
| ALBI score | / | 3.179 (0.436–23.166) | 1.141 | 0.254 | |||
| ICG-R15 | / | 1.009 (1.000–1.017) | 2.071 | 0.038 | 1.007 (0.997–1.017) | 1.411 | 0.158 |
| TBIL | / | 1.031 (0.985–1.080) | 1.317 | 0.188 | 0.989 (0.924–1.059) | −0.306 | 0.760 |
| Cr | / | 1.007 (0.992–1.023) | 0.906 | 0.365 | |||
| INR | / | 570.563 (3.003–108,405.650) | 2.371 | 0.018 | 1.758 (0.001–2,089.404) | 0.156 | 0.876 |
| AST | / | 1.009 (0.999–1.020) | 1.828 | 0.068 | 0.997 (0.977–1.018) | −0.291 | 0.771 |
| ALT | / | 1.006 (0.998–1.013) | 1.476 | 0.140 | 1.006 (0.988–1.024) | 0.657 | 0.511 |
| GGT | / | 1.001 (0.999–1.004) | 1.050 | 0.294 | |||
| PLT | / | 0.997 (0.993–1.001) | −1.458 | 0.145 | 0.990 (0.983–0.997) | −2.895 | 0.004 |
| Tumor size | / | 1.177 (1.057–1.311) | 2.961 | 0.003 | 1.347 (1.139–1.594) | 3.477 | 0.001 |
| Number of tumors | 1 | 1 | / | / | |||
| 2 | 1.200 (0.337–4.279) | 0.281 | 0.779 | ||||
| >3 | 1.000 (0.409–2.444) | −1.73e-16 | 1.000 | ||||
| Vascular invasion | Absent | 1 | 0.332 | 0.740 | |||
| Present | 1.142 (0.521–2.503) | ||||||
| Splenomegaly | Absent | 1 | 1.479 | 0.139 | 1 | −0.831 | 0.406 |
| Present | 2.227 (0.771–6.436) | 0.537 (0.124–2.329) | |||||
| Varicose veins | Absent | 1 | 0.286 | 0.775 | |||
| Present | 1.200 (0.344–4.188) | ||||||
| Adjacent tissue invasion | Absent | 1 | −0.001 | 1.000 | |||
| Present | 0.000 (0.000–inf) | ||||||
| Cirrhosis | Absent | 1 | 1.116 | 0.265 | |||
| Present | 1.704 (0.668–4.344) | ||||||
| Bile duct invasion | Absent | 1 | −0.013 | 0.990 | |||
| Present | 0.982 (0.060–16.099) | ||||||
| Cholangiectasis | Absent | 1 | 0.630 | 0.529 | |||
| Present | 1.530 (0.407–5.750) | ||||||
| Lymph node metastasis | Absent | 1 | −0.912 | 0.362 | |||
| Present | 0.576 (0.176–1.885) | ||||||
| Distant metastasis | Absent | 1 | −0.001 | 1.000 | |||
| Present | 0.000 (0.000–inf) | ||||||
| Tumor capsule | Complete | 1 | / | / | |||
| Incomplete | 1.214 (0.379–3.888) | 0.327 | 0.744 | ||||
| Tumor boundary | Smooth | 1 | / | / | |||
| Rough | 1.515 (0.663–3.464) | 0.985 | 0.325 | ||||
| THPE | Absent | 1 | −0.995 | 0.320 | |||
| Present | 0.619 (0.240–1.594) | ||||||
| Hemorrhage | Absent | 1 | 0.938 | 0.348 | |||
| Present | 1.602 (0.599–4.289) | ||||||
| Tumor thrombus | Absent | 1 | −0.468 | 0.640 | |||
| Present | 0.829 (0.378–1.818) | ||||||