Figure 2.

RNA methylation regulates immunity by affecting RNA translation, degradation, and nuclear export and directly inhibiting RNA immunogenicity. RNA methylation promotes IL-17 translation. RNA methylation promotes the translation of CD40, CD80, and TIRAP and improves antigen presentation by DCs. RNA methylation promotes the translation of lysosomal proteases, degrades antigens and inhibits antigen presentation by DCs. RNA methylation promotes Lnc-Dpf3 degradation to prevent Lnc-Dpf3 from inhibiting DC migration by targeting HIF-1α. DDX46 recruits ALKBH5 to demethylate MAV, Traf3, and Traf6 mRNAs, inhibit the enucleation of mRNAs, and thus inhibit the immune function of MAV, Traf3, and Traf6. Methylation of RNAs suppresses the immunogenicity of RNAs and eliminates or weakens the ability of RNAs to activate the immune response.