FIGURE 1.

PAR2 activating proteases and peptide induces synthesis of tissue factor in HTECs. Induction of tissue factor synthesis in response thrombin (A,B), matriptase (C,D), trypsin (E,F), and 2f-LIGRLO-NH₂ (2F) (G,H) in HTEC by Western blotting. Representative blots for an individual human donor are shown for n ≥ 3. The graphs were established from three separate experiments and indicate changes in band density between different concentrations of the PAR2 agonists treatments. Significant (*p < 0.05 or **p < 0.01) changes in TF band density relative to actin were analyzed by one-way ANOVA with Dunnett’s post hoc test.