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. 2021 Mar 23;4:395. doi: 10.1038/s42003-021-01912-w

Fig. 5. LRRN4CL expression in tumours and its correlation to patient outcome.

Fig. 5

a LRRN4CL expression (RSEM) amongst different tumour types (data from TCGA). Bar represents the median, box represents the interquartile range. Whiskers represent 1.5 * IQR. Abbreviations: HCC hepatocellular carcinoma, THCA well-differentiated thyroid cancer, LEUK leukaemia, SEM seminoma, RNCCC renal non-clear cell carcinoma, BMCN mature B-cell neoplasms, TET thymic epithelial tumour, CHOL cholangiosarcoma, NSCLC non-small cell lung cancer, HNSCC head and neck squamous cell carcinoma, RCCC renal clear cell carcinoma, CSCC cervical squamous cell carcinoma, OSCC oesophageal squamous cell carcinoma, NCGCT non-seminomatous germ cell tumour, BRCA invasive breast carcinoma, GBMLGG diffuse glioma, UC bladder urothelial carcinoma, COADCA colorectal adenocarcinoma, CEAD cervical adenocarcinoma, PCC pheochromocytoma, OSCA oesophagogastric neuroepithelial tumour, MNET miscellaneous neuroepithelial tumour, OET ovarian epithelial tumour, ACC adrenocortical carcinoma, UCEC endometrial carcinoma, MESO pleural mesothelioma, PRAD prostate adenocarcinoma, PAAD pancreatic adenocarcinoma, GBM glioblastoma, SARC sarcoma, SKCM cutaneous melanoma, UM uveal melanoma. b Kaplan–Meier curves for disease-specific survival across all cancer patients from the TCGA dataset. Expression levels of LRRN4CL as lower 25th percentile (‘low LRRN4CL’) or upper 25th percentile (‘high LRRN4CL’). Cox Log-rank P value, age- and sex-adjusted. c Kaplan–Meier curves for disease-specific survival in cutaneous melanoma patients from the TCGA dataset. Expression levels of LRRN4CL as lower 25th percentile (‘low LRRN4CL’) or upper 25th percentile (‘high LRRN4CL’). Cox Log-rank P value, age- and sex-adjusted. d Kaplan–Meier curves for progression-free survival in cutaneous melanoma patients from the phase III adjuvant AVAST-M dataset15. Expression levels of LRRN4CL as lower 25th percentile (‘low LRRN4CL’) or upper 25th percentile (‘high LRRN4CL’). Cox Log-rank P value, univariate analysis. The numbers in brackets on each graph indicate the number of patient samples per group.