Figure 7.

Representative maps of compartmentalized ²³Na signals (Na⁺_b, Na⁺_e, Na⁺_i) as well as transendothelial (ΔNa⁺_end) and transmembrane (ΔNa⁺_mem) gradients in U251, U87, and RG2 tumors. The left column shows the tumor location (white outline) on the anatomical ¹H-MRI for animals bearing (a) U251, (b) U87 and (c) RG2 tumors. The respective three columns show ∫Na⁺_b, ∫Na⁺_e, and ∫Na⁺_i maps. The last two columns on the right show the ΔNa⁺_end and ΔNa⁺_mem maps. In all tumors the ∫Na⁺_b and ∫Na⁺_e are high and low, respectively, and thus are the main drivers for a high ΔNa⁺_end and a low ΔNa⁺_mem.