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. 2021 Mar 23;11:6618. doi: 10.1038/s41598-021-85675-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity of erianthridin (ETD) in A549 and H460 cells. (A) The chemical structure of ETD (3,4-dimethoxy-9,10-dihydrophenanthrene-2,7-diol) is shown. (B) A549 and H460 cells were treated with the indicated concentrations of ETD for 24, 48 and 72 h. Cell viability was analyzed using the MTT assay and is represented as a percentage. (C) A549 and H460 cells were treated with nontoxic concentrations of ETD for 24, 48 and 72 h. Cell proliferation was evaluated by the MTT assay. The rate of cell growth was calculated as a value relative to time 0 h. The data are presented as the mean ± SEM (n = 3). *p < 0.05 vs untreated control cells.