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. 2021 Mar 23;7:59. doi: 10.1038/s41420-021-00443-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a SIRT1 was decreased in the kidney in kidney conditional knockout mice (Sirt1 CKO). Protein levels were analyzed by western blot analysis and GAPDH was used as a loading control. b SIRT1 mRNA levels in the kidney were also reduced in Sirt1 CKO mice. c SIRT1 deficiency further exacerbates kidney fibrosis induced by UUO surgery. Protein levels were analyzed by western blot analysis and GAPDH was used as a loading control. d Quantification of western blot data as shown in c. e Sirt1 deficiency in the kidney stimulates kidney fibrosis-related gene expressions in UUO mice. Gene expression was analyzed by qRT-PCR and 18S has used a house-keeping gene. n = 6. Data are means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001. ns means no significance.