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. 2021 Mar 23;11:6685. doi: 10.1038/s41598-021-86021-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro synergy of YHO-1701 in combination with already-available targeted agents for a total of 33 “combination + cell line” pairs. Drug interactions (synergism or antagonism) were analyzed using the combination index (CI) method. The antiproliferative effect of YHO-1701 and/or molecular-targeted agents was evaluated in a human cancer cell line panel using the WST-8 assay at 48 or 72 h of exposure. CI values were calculated and represented as a synergy “heat map” where a drug combination is synergistic (pink color) if CI ≤ 0.9; additive (white color) if CI is 0.9–1.1; and antagonistic (gray color) if CI > 1.1.