Figure 2.

Place cell firing was not altered by connectivity changes

Analyses exclude goal-directed epochs. See Figures S4A–S4L for analysis of pyramidal non-place cells.

(A) Example cell from Closed-Door sequences. (Top) Foraging rate maps, colors indicate firing rate, number indicates maximum rate, non-shaded areas are used in the doorway correlation analysis in (E), and red circled areas correspond to the locked door. (Bottom) Foraging spike plots, gray: trajectory, red: spikes. See also Figure S2.

(B) Matrix of cell-averaged rate map correlations between all sessions.

(C) Comparison of correlations between two open sessions (O1&O2) and one open and one locked (O2&C1).

(D) Correlations between rate maps as a function of number of sessions between them, 0 = consecutive sessions (O1&O2, O2&C1, etc.), 1 = pairs with 1 session between them (O1&C1, C1&O3, etc.), etc.

(E) Correlations focusing on 25 cm around doors.

(F) The rate remapping index significantly decreased for the comparisons with the connectivity change indicating less, not more, remapping when the connectivity was modified.

(G–L) Same presentation as (A)–(F) for One-Way sequences, with similar results.

(M) Example foraging rate maps.

(N) Histograms showing remapping patterns for all place cells. Red axis labels highlight conditions where remapping could be attributed to a change of connectivity.

(O) Similar to (N) but only for cells with a field within 25 cm of the locked door(s).

See also Video S2 for activity plots of all used place cells, Figures S2–S4.