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. 2021 Mar 23;12(4):309. doi: 10.1038/s41419-021-03599-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Different mutant phenotypes are simulated: A Keap1 depletion (NRF2 activation) is mimicked upon excessive level of cellular stress (stress = 7.5, kaac = 5). B Depletion of autophagy controller is achieved on various levels (stress = 7.5, AUCO-T = 0.01, see lines marked with ‘a’; stress = 0.03, see lines marked with ‘b’; stress = 0.05, see lines marked with ‘c’). Grey background refers to possible cell death. For details about the codes and software used for simulations, see the Supplementary Information.