Table 1.
The expression patterns, mechanism, and functions of circRNAs associated with tumor angiogenesis.
| CircRNA | Expression | Mechanism | Function | Origin | Ref |
|---|---|---|---|---|---|
| circRNA-MYLK | up | miR-29a/VEGFA/VEGFR2/Ras/ERK signaling pathway | proliferation, migration, tube formation of HUVEC and rearranged cytoskeleton | Bladder Cancer | (42) |
| CircHIPK3 /BCRC-2 /hsa_circ_0000284 |
down | miR-558/HPSE | migration, invasion, and angiogenesis | bladder cancer | (43) |
| Circ-ASH2L | up | miR-34a/Notch1 | invasion, proliferation and angiogenesis | Pancreatic Ductal Adenocarcinoma | (44) |
| hsa_circRNA_002178 /hsa_circ_0000519 |
up | miR-328-3p/COL1A1 | cell viability, energy metabolism and tube formation ability | breast cancer | (45) |
| CircSMARCA5 /hsa_circ_0001445 |
down | Splicing Factors SRSF1/VEGFA | cells migration and angiogenesis | glioblastoma multiforme | (46, 47) |
| circ-SHKBP1 /hsa_circ_0000936 |
up | miR-544a/FOXP1/miR-379/FOXP2/AGGF1 | viability, migration, and tube formation of GEC | GECs | (48) |
| circ_002136 | up | FUS/circ_002136/miR-138-5p/SOX13/SPON2 | viability, migration and tube formation | GECs | (49) |
| circ-DICER1 | up | MOV10/circ-DICER1/miR-103a-3p/miR-382-5p/ZIC4/Hsp90β/PI3K/Akt | cell viability, migration, and tube formation of GECs | GECs | (50) |
| Exosome has_circRNA_100338 | up | VE-Cadherin and ZO-1 | cell proliferation, angiogenesis, permeability, and vasculogenic mimicry formation ability of HUVECs | HCC | (51) |
| hsa_circ_0003575 | up | potential circRNA-miRNA-mRNA network | proliferation and angiogenesis ability of HUVECs | HUVECs | (52) |
| hsa_circ_0010729 | up | miR-186/HIF-1α Axis | vascular endothelial cell proliferation and apoptosis | HUVECs | (53) |
| cZNF609 | up | miR-615-5p/MEF2A | retinal vessel loss and suppressed pathological angiogenesis | high glucose and hypoxia stress | (54) |
| circNfix /hsa_circ_0005660 |
up | miR-214/Gsk3β/β-catenin/Meis1(TF) Ybx1,Nedd4l cyclin A2,cyclin B1 | proliferation angiogenesis and apoptosis | adult heart in humans, rats, and mice | (55) |
| circHIPK3 | up | miR-30a-3p/VEGF-C, FZD4, and WNT2 | cell viability, proliferation, migration, and tube formation | diabetic retinas and retinal endothelial cells | (56) |
| hsa_circ_0074834 | down | microRNA-942-5p/ZEB1/VEGF | promote osteogenic differentiation of BMSCs and the repair of bone defects | BMSC | (57) |
| Circ_0063517 | down | miR-31-5p-ETBR | growth, migration, and angiogenesis | placenta tissue of PE | (58) |