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. 2021 Mar 23;4:392. doi: 10.1038/s42003-021-01910-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Manhattan plot depicting p-values of the 564,159 exonic variants tested for association with IPF status in 752 cases and 119,055 controls. The long-dash line indicates the genome-wide significance threshold (p < 5 × 10⁻⁸). Relevant to the MUC5B locus, the Y-axis is capped at 1 × 10⁻¹⁰. b Quantile–quantile plot of observed versus expected p-values. Linear regression line is indicated in red.