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. 2021 Mar 23;7:16. doi: 10.1038/s41421-021-00247-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The overall structure of the LAT1-4F2hc bound with Diiodo-Tyr. The structure on the left is the EM map of the complex. The structure on the right is the overall structure of the complex. The glycosylation moieties are shown as sticks. H, helix. 4F2hc and LAT1 are colored orange and blue, respectively. b Diiodo-Tyr binding mode in LAT1. c LAT1 has a broad extracellular vestibule above Diiodo-Tyr.