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. 2021 Mar 23;4:390. doi: 10.1038/s42003-021-01903-x

Fig. 1. Coagulation factor IX structural domains and posttranslational modifications.

Fig. 1

Schematic of mature factor IX (FIX) with previously described posttranslational modifications (PTMs) in plasma-derived FIX and/or recombinant FIX (figure modified from ref. 30). The GLA domain (red) contains 12 potential sites of γ-carboxylation on E7–40 and one O-glycan at T38/39. The EGF-like 1 domain (pink) contains two O-glycans on S53 and S61, β-hydroxylation of D64, and phosphorylation of S68. The EGF-like 2 domain (violet) has no known PTMs. The short domain (white) linking the EGF-like 2 domain with the activation peptide (AP, green) contains one O-glycan at S141. The AP contains two N-glycans at N157 and N167, four O-glycans at T159, T169, T172, and T179, sulfation of Y155, and phosphorylation of S158 and T159. The serine protease domain (orange) contains one N-linked glycan at N258.