Table 3.
Cox regression models of the predictors of graft failure and recipient death by multivariate analysis.
| Graft failure | Recipient death | |||||||
|---|---|---|---|---|---|---|---|---|
| IL-6 | CXCL10 | IL-6 | CXCL10 | |||||
| Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | |
| Kidney transplant | ||||||||
| Donor age | 1.01 (0.99–1.03) | 0.253 | 1.01 (0.99–1.03) | 0.253 | 1.04 (1.03–1.06) | < 0.001 | 1.05 (1.03–1.06) | < 0.001 |
| Panel Reactive Antibody (max) | 1.01 (0.99–1.02) | 0.201 | 1.01 (0.99–1.02) | 0.203 | 1.01 (0.99–1.02) | 0.480 | 1.01 (0.99–1.02) | 0.480 |
| Immunologic risk (yes/no) | 0.61 (0.17–2.13) | 0.436 | 0.61 (0.17–2.13) | 0.437 | 1.35 (0.62–2.91) | 0.473 | 1.32 (0.61–2.85) | 0.473 |
| NITK3 | 0.79 (0.53–1.16) | 0.229 | 0.79 (0.53–1.16) | 0.229 | – | – | ||
| Cold ischemia time (min) | 1.02 (0.98–1.06) | 0.241 | 1.02 (0.98–1.06) | 0.241 | – | – | ||
| Donor: hypertension | 1.43 (0.91–2.24) | 0.120 | 1.43 (0.91–2.23) | 0.120 | 1.34 (0.86–2.08) | 0.182 | 1.35 (0.87–2.01) | 0.182 |
| Donor: cerebral vascular accident | 1.55 (0.96–2.5) | 0.074 | 1.55 (0.96–2.5) | 0.075 | – | – | ||
| Donor: inotrope administered | 1.36 (0.95–1.94) | 0.097 | 1.36 (0.95–1.95) | 0.097 | – | – | ||
| Donor cytokine (log pg/ml) | 0.99 (0.71–1.37) | 0.936 | 0.99 (0.71–1.37) | 0.934 | 1.18 (0.87–1.61) | 0.29 | 0.93 (0.57–1.5) | 0.76 |
| High IL-6/CXCL10a | 0.976 (0.59–1.62) | 0.926 | 1.604 (1.019–2.525) | 0.041 | ||||
| Liver transplant | ||||||||
| Recipient age | 0.982 (0.97–0.99) | 0.022 | 0.98 (0.97–0.99) | 0.028 | – | – | ||
| Numbers of HLA mismatch | 1.097 (1.01–1.2) | 0.036 | 1.09 (1–1.19) | 0.049 | 1.01 (0.92–1.11) | 0.81 | 1.01 (0.92–1.11) | 0.85 |
| Panel reactive antibody (max) | – | – | 1.01 (1–1.02) | 0.067 | 1.01 (1–1.02) | 0.081 | ||
| Donor: hypertension | – | – | 1.31 (0.94–1.8) | 0.112 | 1.35 (0.97–1.89) | 0.077 | ||
| Donor cytokine (log pg/ml) | 1.43 (1.09–1.88) | 0.01 | 1.5 (1–2.24) | 0.05 | 1.36 (1.06–1.75) | 0.016 | 1.45 (1–2.1) | 0.052 |
| High IL-6/CXCL10a | 1.614 (1.08–2.4) | 0.019 | 1.61 (1.12–2.32) | 0.011 | ||||
| Heart transplant | ||||||||
| Donor age | 1.03 (1–1.01) | 0.079 | 1.03 (0.99–1.07) | 0.081 | 1.02 (0.99–1.05) | 0.177 | 1.02 (0.99–1.04) | 0.18 |
| Recipient age | 1.01 (0.98–1.03) | 0.76 | 1.00 (0.98–1.03) | 0.79 | – | – | ||
| Waiting times for transplant (days) | – | – | 1 (1–1.01) | 0.095 | 1 (1–1.01) | 0.095 | ||
| Donor: cardiac arrest | – | – | 1.88 (0.96–3.7) | 0.065 | 1.87 (0.95–3.7) | 0.068 | ||
| Donor: cerebral vascular accident | 3.36 (0.77–14.7) | 0.11 | 3.75 (0.86–16.3) | 0.078 | 2.13 (1.13–4.03) | 0.019 | 2.16 (1.14–4.11) | 0.018 |
| Donor: trauma | 1.16 (0.22–6.1) | 0.86 | 1.3 (0.25–6.7) | 0.76 | – | – | ||
| Donor cytokine (log pg/ml) | 1.49 (0.83–2.68) | 0.18 | 1.94 (0.82–4.6) | 0.13 | 0.95 (0.59–1.53) | 0.829 | 1.17 (0.61–2.27) | 0.63 |
| High IL-6/CXCL10a | 2.15 (0.96–4.8) | 0.064 | 1.52 (0.72–3.18) | 0.28 | ||||
For each cytokine, donor and recipient characteristics with p values < 0.05 in univariate analysis were included in the multivariate analysis.
aInserted instead of donor cytokine.