Figure 5.

Mean intrinsic coupling for control subjects and children and adolescent offspring of patients with schizophrenia (HR-SCZ subjects) for the winning model depicted in Figure 3C. Significantly reduced intrinsic connectivity is observed in the HR-SCZ subjects with reduced excitatory connectivity particularly notable in frontolimbic pathways, that is, in the affective core of the circuit. *P=.01, Bonferroni corrected (eTable 2). Error bars represent standard deviations derived from Bayesian parameter averages. DPFC indicates dorsal prefrontal cortex; FG, fusiform gyrus; V1, primary visual cortex; and VPFC, ventral prefrontal cortex.