Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 10;12:633167. doi: 10.3389/fimmu.2021.633167

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Donninelli, Studer, Brambilla, Zecca, Peluso, Laroni, Michelis, Mantegazza, Confalonieri and Volpe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The CSF of patients with progressive MS contains two clusters of immune soluble factors. The correlation matrix among all soluble factors expressed in the CSF of patients with progressive MS with minimal-to-moderate disability (EDSS < 4) (n = 17) (A), patients with progressive MS with high disability (EDSS ≥ 4) (n = 21) (B), and patients with relapsing-remitting MS (RR-MS) (n = 11) (C). Pearson's correlation coefficients r ≥ 0.5 or ≤ 0.5 are shown. Crossed squares lack statistical significance (p > 0.05). The color in each square indicates the Pearson's correlation coefficient r among the variables reported in the two coordinates, as indicated by colored scale bar. The dashed boxes showed two clusters of cytokines and chemokines reciprocally correlated in A: IFN-γ, MCP-1, MIP-1α, MIP-1β, IL-8, IP-10, and TNF-α (group 1), and IL-9, IL-15, VEGF, and IL-1ra (group 2).