Table 2.

SIRs for SPMs at all anatomical sites combined among CRC survivors stratified by sex, race, age, year, grade, site, stage, and histological subtype.

	CA			MA			SRCC
	Obs	SIR	95% CI	Obs	SIR	95% CI	Obs	SIR	95% CI
Sex
Male	14,679	1.10*	1.08–1.11	1,342	1.15*	1.09–1.22	93	1.49*	1.2–1.82
Female	9,597	1.20*	1.18–1.22	1,119	1.37*	1.3–1.46	68	1.48*	1.15–1.87
Race
White	19,895	1.10*	1.09–1.12	2,062	1.21*	1.16–1.27	134	1.38*	1.15–1.63
Black	2,704	1.22*	1.18–1.27	276	1.37*	1.22–1.55	17	2.54*	1.48–4.06
Other	1,677	1.46*	1.39–1.53	123	1.64*	1.36–1.96	10	2.19*	1.05–4.03
Age at diagnosis
20–49	1,630	1.90*	1.81–2	220	2.64*	2.3–3.01	35	5.33*	3.71–7.41
50–64	8,501	1.16*	1.14–1.19	760	1.25*	1.17–1.35	50	1.48*	1.1–1.95
65–79	14,145	1.07*	1.05–1.09	1,481	1.15*	1.09–1.21	76	1.11	0.88–1.39
Year of diagnosis
2000–2004	12,571	1.07*	1.05–1.08	1,477	1.23*	1.17–1.3	87	1.46*	1.17–1.8
2005–2009	9,273	1.19*	1.17–1.22	805	1.24*	1.16–1.33	60	1.50*	1.14–1.93
2010–2011	2,432	1.33*	1.28–1.39	179	1.38*	1.19–1.6	14	1.54	0.84–2.58
Grade
I	2,821	1.10*	1.06–1.14	320	1.22*	1.09–1.36	2	1.28	0.15–4.62
II	17,926	1.13*	1.11–1.15	1,683	1.24*	1.19–1.3	16	1.48	0.84–2.4
III	3,322	1.18*	1.14–1.22	421	1.25*	1.14–1.38	133	1.50*	1.25–1.77
IV	207	1.30*	1.13–1.49	37	1.45*	1.02–2	10	1.35	0.65–2.48
Site
Right colon	9,528	1.18*	1.16–1.2	1,514	1.26*	1.2–1.33	109	1.55*	1.27–1.87
Left colon	8,115	1.15*	1.13–1.18	568	1.31*	1.2–1.42	25	1.47	0.95–2.17
Rectum	6,633	1.06*	1.03–1.08	379	1.1	0.99–1.22	27	1.27	0.83–1.84
Stage
Distant	1,145	1.08*	1.02–1.15	150	1.26*	1.06–1.48	13	1.38	0.73–2.36
Localized	13,212	1.14*	1.12–1.15	1,065	1.29*	1.21–1.37	44	1.45*	1.05–1.94
Regional	9,919	1.14*	1.12–1.16	1,246	1.21*	1.14–1.28	104	1.51*	1.24–1.83

CA, classical adenocarcinoma; MA, mucinous adenocarcinoma; SRCC, signet-ring cell carcinoma; Obs, observed events; SIR, standard incidence ratio; CI, confidence interval;

^*P < 0.05 (compared with general population).