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. 2021 Mar 10;11:620435. doi: 10.3389/fonc.2021.620435

Figure 2.

Figure 2

The diagram of CIITA-CREBBP fusion by next generation sequencing using formalin-fixed paraffin-embedded tissue. The first 19 exons of CIITA are fused with exons of 22–31 of CREBBP. Since exon 19 of CIITA contains a stop codon and a portion of 3′-untranslated region (UTR) at 5′ of exon 22 of CREBBP on the RNA, the fusion is postulated to generate a functional CIITA but a non-functional CREBBP.