Table 6.
Linear regression models (adjusted for smoking) for the associations between severity of schizophrenia/depressive symptoms and mRNA expression or ratios of mRNA expression for dopamine and serotonin receptors in PBMCs of study subjects.
| PANSS total | PANSS!!break P | PANSS N | PANSS G | CDSS | R2 | |
|---|---|---|---|---|---|---|
| D3 | NS | NS | NS | NS | −0.27 | 0.31 |
| D4 | NS | NS | NS | NS | −5.54 | 0.32 |
| 5–HT1A | NS | NS | NS | NS | −0.51 | 0.31 |
| 5–HT2A | NS | NS | NS | NS | −1.74 | 0.31 |
| 5-HT3A | NS | NS | NS | NS | −0.04 | 0.31 |
| D4:D3 | NS | NS | NS | NS | 0.09 | 0.25 |
| D4:5-HT3A | NS | NS | NS | NS | −0.99 | 0.23 |
| 5-HT1A:D3 | NS | NS | NS | NS | −0.08 | 0.26 |
| 5-HT1A:D4 | NS | NS | NS | NS | 0.01 | 0.26 |
| 5-HT1A:5-HT2A | NS | NS | NS | NS | 0.01 | 0.25 |
| 5-HT1A:5-HT3A | NS | NS | NS | NS | 0.33 | 0.26 |
| 5-HT2A:D3 | NS | NS | NS | NS | 0.16 | 0.26 |
| 5-HT2A:D4 | NS | NS | NS | NS | 0.01 | 0.25 |
| 5-HT2A:5-HT3A | NS | NS | NS | NS | 0.48 | 0.25 |
| 5-HT3A:D3 | NS | NS | NS | NS | 0.01 | 0.25 |
| 5-HT3A:D4 | NS | NS | NS | NS | 0.01 | 0.25 |
Data shown as β (standardized coefficient), R2 = coefficient of determination.
All p < 0.05.
NS, non-significant.