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. 2021 Mar 10;12:618213. doi: 10.3389/fendo.2021.618213

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Copyright © 2021 Frommer and Kahaly

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Binding mechanisms of islet and thyroid peptides. Two potential mechanisms for immunologically targeting several glands in patients with polyglandular autoimmunity. Panel (A) One APC expresses both pancreas as well as thyroid autoantigens (peptides) which are embedded in pockets with HLA class II molecules and presented to the T cell within the immunological synapse. Panel (B) Two APC express either a pancreas or thyroid antigen, however both APC share a common amino acid, which facilitates the anchoring of T cells.