Table 2.
List of population based susceptibility genes for T1D, AITD, and AP subtype III variant.
| Gene | Diseases | Country | Ethnecity | Reference |
|---|---|---|---|---|
| CTLA4 | T1D | Middle East & North Africa | Arab | Hatem Zayed, 2016 (2) |
| T1D | Poland | Caucasoid | Hanna Borysewicz-Sanczyk, 2020 (134) | |
| T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) | |
| AITD | Great Britain, China | Caucasoid, Asian | Yul Hwangbo, 2018 (136) | |
| T1D AITD | Japan | Asian | Takuya Awata, 2008 (56) | |
| T1D AITD | Japan | Asian | Hisakuni Yamashita, 2011 (88) | |
| T1D AITD | Japan | Asian | Ichiro Horie, 2012 (87) | |
| T1D AITD | Sweden | Caucasoid | Dan Holmberg, 2016 (119) | |
| PTPN22 | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) | |
| AITD | Jordan | Arab | Asem Alkhateeb, 2013 (137) | |
| AITD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) | |
| T1D AITD | Sweden | Caucasoid | Dan Holmberg, 2016 (119) | |
| IL2RA | T1D | Japan | Asian | Hisakuni Yamashita, 2011 (88) |
| T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) | |
| T1D | Poland | Caucasoid | Hanna Borysewicz-Sanczyk, 2020 (134) | |
| AITD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) | |
| IFIH1 | T1D | Japan | Asian | Hisakuni Yamashita, 2011 (88) |
| T1D | Poland | Caucasoid | Hanna Borysewicz-Sanczyk, 2020 (134) | |
| T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) | |
| T1D AITD | Sweden | Caucasoid | Dan Holmberg, 2016 (119) | |
| INS | T1D | Japan | Asian | Hisakuni Yamashita, 2011 (88) |
| T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) | |
| T1D AITD | Sweden | Caucasoid | Dan Holmberg, 2016 (119) | |
| CLEC16A | T1D AITD | Japan | Asian | Takuya Awata, 2008 (56) |
| T1D AITD | Japan | Asian | Hisakuni Yamashita, 2011 (88) | |
| ERBB3 | T1D AITD | Japan | Asian | Takuya Awata, 2008 (56) |
| T1D AITD | Japan | Asian | Hisakuni Yamashita, 2011 (88) | |
| CD28 | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| CD40 | GD | Japan | Asian | Naoya Inoue, 2012 (118) |
| CD69 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| CD226 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| CD247 | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| T1D AITD | Sweden | Caucasoid | Dan Holmberg, 2016 (119) | |
| TNF | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IL2 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IL10 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IL21 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IL27 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IL7R | T1D | Japan | Asian | Hisakuni Yamashita, 2011 (88) |
| T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) | |
| IL15 | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| VDR | T1D AITD | Brazil | Hispanic | Denise Barreto Mory et al., 2016 (105) |
| NAA25 | T1D AITD | Sweden | Caucasoid | Dan Holmberg, 2016 (119) |
| TRB | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| SLC26A4 | AITD | Tunisia | Arab | Rihab Kallel-Bouattour, 2017 (138) |
| SESN3 | AITD | Chinese Han | Asian | Wei Liu, 2018 (139) |
| FCRL3 | GD | Japan | Asian | Naoya Inoue, 2012 (118) |
| GD | China | Asian | Yul Hwangbo, 2018 (136) | |
| ZFAT | HT | Japan | Asian | Naoya Inoue, 2012 (118) |
| STAT4 | T1D AITD | Korea | Asian | Yongsoo Park, 2011 (140) |
| BANK1 | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| ZAP70 | T1D | Tunisia | Arab | Hatem Zayed, 2016 (2) |
| SMOC2 | AITD | Jordan | Arab | Asem Alkhateeb, 2013 (137) |
| BACH2 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| AITD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) | |
| IKZF1 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IKZF3 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| IKZF4 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| AFF3 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| CCR5 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| T1D AITD CD | Poland | Caucasoid | Bartosz Słomiński, 2017 (141) | |
| CCR7 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| GLIS3 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| SH2B3 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| HT | United States | Caucasoid | Yul Hwangbo, 2018 (136) | |
| GRP183 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| RASGRP1 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| CTSH | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| DEXI | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| BCAR1 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| FUT2 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| UBASH3A | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| ICOSLG | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| RAC2 | T1D | Great Britain | Caucasoid | Suna Onengut-Gumuscu 2015 (135) |
| GD | China | Asian | Yul Hwangbo, 2018 (136) | |
| TSHR | GD | Great Britain, China | Caucasoid, Asian | Yul Hwangbo, 2018 (136) |
| RNASET2 | AITD | Great Britain, China | Caucasoid, Asian | Yul Hwangbo, 2018 (136) |
| CHRNA9 | GD | China | Asian | Yul Hwangbo, 2018 (136) |
| MMEL1 | GD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) |
| PRICKLE1 | GD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) |
| ITGAM | GD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) |
| GPR174 | GD | China | Asian | Yul Hwangbo, 2018 (136) |
| SLAMF6 | GD | China | Asian | Yul Hwangbo, 2018 (136) |
| ABO | GD | China | Asian | Yul Hwangbo, 2018 (136) |
| LINC01550 | GD | China | Asian | Yul Hwangbo, 2018 (136) |
| TG | GD | China | Asian | Yul Hwangbo, 2018 (136) |
| FOXE1 | HT | United States | Caucasoid | Yul Hwangbo, 2018 (136) |
| VAV3 | HT | United States, Japan | Caucasoid, Asian | Yul Hwangbo, 2018 (136) |
| CAPZB | HT | United States | Caucasoid | Yul Hwangbo, 2018 (136) |
| PDE8B | HT | United States | Caucasoid | Yul Hwangbo, 2018 (136) |
| TRIB2 | AITD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) |
| LPP | AITD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) |
| FAM76B | AITD | Great Britain | Caucasoid | Yul Hwangbo, 2018 (136) |
T1D, Type 1 diabetes; AITD, Autoimmune thyroid disease; GD, Graves’ disease; HT, Hashimoto’s thyroiditis; CD, Celiac disease; CTLA4, cytotoxic T-lymphocyte associated protein 4; PTPN22, protein tyrosine phosphatase non-receptor type 22; IL2RA, interleukin 2 receptor subunit alpha; IFIH1, interferon-induced with helicase C domain 1; INS, insulin gene; CLEC16A, C-Type Lectin Domain Containing 16; ERBB3, Erb-B2 Receptor Tyrosine Kinase 3; CD28, cluster of differentiation 28; CD40, cluster of differentiation 40; CD3z, cluster of differentiation 3z; CD247, cluster of differentiation 247; IL7R, interleukin-7 receptor; IL15, interleukin-15; VDR, Vitamin D receptor; NAA25, N-Alpha-Acetyltransferase 25; TCRβ, T-cell receptor beta; SLC26A4, solute carrier family 26 member 4; CCR)5-(Δ32), Chemokine receptor type (CCR)5 - 32-bp deletion (Δ32); SESN3, Sestrin3; FCRL3, Fc receptor-like protein 3; ZFAT, Zinc Finger And AT-Hook Domain Containing; STAT4, Signal transducer and activator of transcription 4; BANK1, B Cell Scaffold Protein With Ankyrin Repeats 1; ZAP70, Zeta-chain-associated protein kinase 70; SMOC2, SPARC-related modular calcium-binding protein 2; BACH2, BTB domain and CNC homolog 2; IKZF1, IKAROS family zinc finger 1; IKZF3, IKAROS family zinc finger 3; IKZF4, IKAROS family zinc finger 4; AFF3, AF4/FMR2 family member 3; CCR5, C-C motif chemokine receptor 5; CCR7, C-C motif chemokine receptor 7; GLIS3, GLIS family zinc finger 3; SH2B3, SH2B adaptor protein 3; GRP183, G protein-coupled receptor 183; RASGRP1, RAS guanyl releasing protein 1; CTSH, cathepsin H; DEXI, Dexi homolog; BCAR1, BCAR1 scaffold protein, Cas family member; FUT2, fucosyltransferase 2; UBASH3A, ubiquitin associated and SH3 domain containing A; ICOSLG, inducible T cell costimulator ligand; RAC2, Rac family small GTPase 2; TSHR, thyroid stimulating hormone receptor; RNASET2, ribonuclease T2; CHRNA9, cholinergic receptor nicotinic alpha 9 subunit; MMEL1, membrane metalloendopeptidase like 1; PRICKLE1, prickle planar cell polarity protein 1; ITGAM, integrin subunit alpha M; GPR174, G protein-coupled receptor 174; SLAMF6, SLAM family member 6; ABO: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase; LINC01550, long intergenic non-protein coding RNA 1550; TG, thyroglobulin; FOXE1, forkhead box E1; VAV3, vav guanine nucleotide exchange factor 3; CAPZB, capping actin protein of muscle Z-line subunit beta; PDE8B, phosphodiesterase 8B; TRIB2, tribbles pseudokinase 2; LPP, LIM domain containing preferred translocation partner in lipoma; FAM76B, family with sequence similarity 76 member B.