Figure 2.

Summary of sclerostin-mediated effects on adipose tissue and on mineral metabolism. Recombinant sclerostin exerts direct effects on adipocytes and kidney proximal tubule cells in culture. Mice overproducing sclerostin demonstrate increased adiposity and reduced glucose tolerance. Reduced sclerostin in vivo, achieved through inactivating mutations, conditional ablation, or neutralizing antibodies, leads to reduced adiposity, improved glucose handling, and altered mineral metabolism in mice.