Figure 4.
Salivary bacterial biomarkers for classifying different stages of gastric carcinogenesis. (A) Microbiological features of the salivary microbiota associated with different histological stages of gastric tumorigenesis. Bacteria taxa that enriched in each histological stage were determined by LEfSe with Kruskal–Wallis test P <0.05 and log 10 LDA score >3.4. (B) ROC curves analysis to evaluate the discriminatory potential of salivary bacteria in identifying GC out of pre-malignant lesions. (C) The top 10 bacterial genera that are most important for discriminating GC with non-malignant types. Each genus is ranked according to an importance score (mean decrease accuracy).