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. 2021 Mar 10;11:623276. doi: 10.3389/fimmu.2020.623276

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Copyright © 2021 Meneghini, Crespo, Niemann, Torija, Lloberas, Pernin, Fontova, Melilli, Favà, Montero, Manonelles, Cruzado, Palou, Martorell, Grinyó and Bestard

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between amino acid MM, eplet MM load, and PIRCHE-II score for each donor DQ molecule and the respective dnDSA formation. Each dot illustrates the single molecular MM score of each donor DQ molecule against which the patients developed or not dnDSA. (A) Amino acid MM 6.5 ± 7.9 vs 17.6 ± 7.4, p<0.001. Solvent accessible 4.82 ± 6.18 vs 12.87 ± 6.29, p<0.001. (B) Eplet MM load 3.56 ± 4.33 vs 8.27 ± 2.95, p<0.001. Antibody-verified 1.31 ± 1.87 vs 2.82 ± 1.26, <0.001. (C) PIRCHE-II 8.98 ± 11.54 vs 23.2 ± 10.84, p<0.001. MM, mismatch; dnDSA, de novo donor-specific antibody.