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Anterograde and retrograde modeling
Schematic of the anterograde (mRNA to protein) and retrograde (protein to mRNA) modeling. For the anterograde (retrograde) model, the mRNA (protein) measured experimentally is used as input to calculate the protein (mRNA) dynamics. The obtained protein (mRNA) profile undergoes a fitting procedure to find the best parameters for the synthesis and degradation rates to match the experimentally observed protein (mRNA) dynamics.
