Table 1.

Overview of previously reported treatments for idiopathic scrotal dysesthesia

Treatment	Proposed mechanism	Previously reported dosing regimen	Response	Level of evidence∗	Citation
Doxycycline	Anti-inflammatory	100 mg BID for 1 month then QD until resolution	Improvement within 2-4 weeks, and complete resolution within 1-4 months	IV	Abbas et al, 20084
Doxycycline + Amitriptyline	Anti-inflammatory and neural modulation	Doxycycline (100 mg BID) and Amitriptyline (50-75 mg per day)	Near-complete resolution by 1.5-3 months	IV	Narang et al, 20135
Doxycycline+ Tacrolimus	Anti-inflammatory	Doxycycline QD and tacrolimus 0.1% ointment BID	Complete remission within 4 weeks	IV	Wollina, 20116
Doxycycline + Pregabalin	Anti-inflammatory and neural modulation	Doxycycline (100 mg BID) and pregabalin	Near-complete resolution by 1.5-3 months	IV	Narang et al, 20135
Gabapentin	Neural modulation	NA	Mild improvement after 2 weeks	IV	Wollina, 20116
Pregabalin	Neural modulation	50 mg TID	Complete remission	IV	Miller et al, 20167
		150 mg QID for 3 months	Complete remission	IV	Cardenas-de La Garza, 20198
Ivermectin	Anti-inflammatory	12 mg (oral) QW for 4 weeks then 10 mg/g topical cream QD until resolution	Improvement within 4 weeks	IV	Martinez et al, 20209
Carvedilol	Vasoconstriction of the cutaneous arteries	6.25 mg QD	Improvement after 2 weeks and complete remission after 4 weeks	IV	Merhi et al, 201710
Timolol	Vasoconstriction of the cutaneous arteries	Topical 0.5% gel	Improvement within 2 weeks	IV	Pyle et al, 201911

BID, Twice daily; QD, once daily; QW, once weekly; TID, thrice daily.

^∗Based on the Oxford Center Evidence-based Medicine, Levels of Evidence Pyramd.