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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Curr Opin Microbiol. 2021 Feb 6;60:16–23. doi: 10.1016/j.mib.2021.01.009

Figure 1. Structures of the Bam complex and the budding model for folding.

Figure 1.

(a) Structure of the BamABCDE complex in which the lateral gate of BamA is closed (PDB: 5D0O). (b) Top-down view of complex in (a). (c) Structure of the BamABCDE complex in which the lateral gate of BamA is open (PDB: 5LJO). (d) Top-down view of complex in (c). (e) Overlay of the β-barrel domain of BamA from a structure with a closed lateral gate (teal; PDB: 5D0O) and a structure with an open lateral gate (orange; PDB: 5EKQ). In the lateral-open structure, the initial β-strands are flipped outward approximately 60 degrees. (f) The budding model for β-barrel assembly into the outer membrane.