Table 4.
Histopathologic scoring method.
| m-TiO2NPs in organs | |
| 0 | Absent |
| 1 | 1-2 NPs/HPF∗ |
| 2 | 3-4 NPs/HPF |
| 3 | ≥4 NPs/HPF |
| Cell necrosis | |
| 0 | Absent |
| 1 | Focal occurrence of 1–5 necrotic cells/HPF |
| 2 | Diffuse occurrence of 1–5 necrotic cells/HPF |
| 3 | Same as 2 + focal occurrence of 1–5 necrotic cells/HPF |
| 4 | Diffuse occurrence of ≥6 necrotic cells/HPF |
| Leukocyte or neutrophil infiltrate | |
| 0 | Absent |
| 1 | 1–5 infiltrated cell/HPF |
| 2 | ≥6 infiltrated cell/HPF |
| Polymorphonuclear cells | |
| 0 | Absent |
| 1 | 1–5 infiltrated cell/HPF |
| 2 | ≥6 infiltrated cell/HPF |
| Macrophages, | |
| 0 | Absent |
| 1 | 1–5 infiltrated cell/HPF |
| 2 | ≥6 infiltrated cell/HPF |
| Plasma cells | |
| 0 | Absent |
| 1 | 1–5 infiltrated cell/HPF |
| 2 | ≥6 infiltrated cell/HPF |
| Eosinophils lymphocyte | |
| 0 | Absent |
| 1 | 1–5 infiltrated cell/HPF |
| 2 | ≥6 infiltrated cell/HPF |