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. 2021 Mar 21;6(10):3437–3448. doi: 10.1016/j.bioactmat.2021.03.010

Fig. 7.

Fig. 7

In situ implantation of PT and GMPT scaffolds, micro-CT 3D reconstruction and biomechanical test of PT and GMPT in critical radius defects of rabbits. (a) Schematic illustration of GMPT in vivo implantation. (b) The surgical process of GMPT implantation in rabbits with critical radius defects. (c) Micro-CT reconstruction of bone regeneration with the scaffolds at 4 and 12 weeks postsurgery. The new bones were brown color. (d) Bone volume/total volume (BV/TV) analysis of the bone defect 4 and 12 weeks after surgery. (e) Bone mineral density (BMD) analysis of regenerated bone 4 and 12 weeks after surgery. (f) Schematic illustration of the direct mechanical testing for in vivo samples. (g) The maximum load of direct mechanical testing for implanted scaffolds. These results demonstrated that the prognosis of in situ implantation of GMPT scaffolds in critical radius defects was preferable to that of PT scaffolds. Overall, 10% GMPT showed the best results, in accordance with the in vitro test. *represents P＜0.05, ** represents P＜0.01, *** represents P＜0.001.