Table 4.
Correlations of most recent MELD score with Clinical Parameters, Growth Factors and Vascular Injury Markers measured at an earlier time-point
| Parameters (Time-Point A) | MELD Score (Time-Point B) | ||
|---|---|---|---|
| r | p | n | |
| Ishak fibrosis | 0.55 | 0.0044* | 25 |
| PT-INR | 0.63 | 0.0063* | 17 |
| VCAM1 | 0.45 | 0.0242* | 25 |
| P-Selectin | −0.42 | 0.0351* | 25 |
| ICAM-3 | 0.41 | 0.0412* | 25 |
| TGFβ1 | −0.39 | 0.0535 | 25 |
| Platelets | −0.40 | 0.0545 | 24 |
| PDGFAA | −0.38 | 0.058 | 25 |
| PDGF-BB | −0.38 | 0.0583 | 25 |
| Albumin | −0.36 | 0.0873 | 24 |
| Direct bilirubin | 0.35 | 0.0955 | 24 |
| TM | 0.32 | 0.1179 | 25 |
| PP Inflammation | 0.33 | 0.1202 | 23 |
| AST | 0.31 | 0.1472 | 24 |
| Total bilirubin | 0.22 | 0.3067 | 24 |
| Total Inflammation | 0.20 | 0.371 | 23 |
| E-Selectin | 0.16 | 0.4457 | 25 |
| ALP | 0.15 | 0.4883 | 24 |
| ALT | 0.14 | 0.5048 | 24 |
| VEGF | −0.13 | 0.5223 | 25 |
| ICAM-1 | 0.13 | 0.5235 | 25 |
Correlations were calculated by Spearman’s rank correlation between MELD score from the most recent time-point (B) and biopsy scores, GFs and VIMs, and clinical parameters, measured from an earlier time-point (A) in the same patients. Spearman’s rank correlation coefficient, r (rho), p value, and n, number of data points for each variable, are shown above.
indicates statistical significance using p-values at a cut-off of <0.05.
PP: Periportal, ALT, alanine transaminase; AST, aspartate transaminase; ALP, alkaline phosphatase; PT-INR, prothrombin time international normalized ratio; MELD, Model for End stage Liver Disease, TM: Thrombomodulin.