Table 3.
Cox-proportional hazards model assessing the relationship between hs-TnI and mortality during follow-up adjusted for multiple relevant covariates.
| Variable | Non-adjusted |
Adjusted |
||||
|---|---|---|---|---|---|---|
| HR (95%CI) | SE | p value | HR (95%CI) | SE | p value | |
| hs-TnI (per-5-logarithmic units) | 6.38 (5.00–8.15) | 0.80 | <0.001 | 2.52 (1.57–4.04) | 0.61 | <0.001 |
| Age (per-5-year) | 1.36 (1.29–1.45) | 0.04 | <0.001 | 1.07 (1.05–1.09) | 0.01 | <0.001 |
| Male sex | 1.95 (1.40–2.71) | 0.33 | <0.001 | 2.42 (1.62–3.62) | 0.50 | <0.001 |
| Time symptoms-diagnosis (per day) | 0.97 (0.95–1.00) | 0.01 | 0.038 | 1.00 (0.97–1.03) | 0.02 | 0.992 |
| Hypertension | 1.92 (1.43–2.58) | 0.29 | <0.001 | 0.93 (0.65–1.35) | 0.18 | 0.716 |
| Diabetes | 1.35 (0.96–1.88) | 0.23 | 0.084 | 0.93 (0.61–1.42) | 0.20 | 0.745 |
| Dyslipidemia | 1.76 (1.31–2.36) | 0.26 | <0.001 | 0.96 (0.67–1.38) | 0.18 | 0.818 |
| Coronary heart disease | 1.29 (0.77–2.16) | 0.34 | 0.324 | 0.35 (0.16–0.75) | 0.14 | 0.007 |
| Heart failure | 1.49 (0.76–2.91) | 0.51 | 0.244 | 1.03 (0.46–2.33) | 0.43 | 0.938 |
| Atrial fibrillation | 3.67 (2.31–5.85) | 0.87 | <0.001 | 1.27 (0.67–2.39) | 0.41 | 0.462 |
| TIA/stroke | 2.85 (1.82–4.45) | 0.65 | <0.001 | 1.61 (0.89–2.90) | 0.48 | 0.112 |
| CKD | 2.70 (1.80–4.03) | 0.55 | <0.001 | 2.30 (1.33–3.97) | 0.64 | 0.003 |
| PAD | 4.18 (2.85–6.12) | 0.81 | <0.001 | 1.84 (1.08–3.12) | 0.50 | 0.025 |
| EPOC | 1.43 (0.85–2.38) | 0.37 | 0.174 | 0.89 (0.48–1.66) | 0.28 | 0.724 |
| SBP at admission (per mmHg) | 1.00 (0.99–1.00) | 0.00 | 0.296 | 0.99 (0.99–1.00) | 0.00 | 0.137 |
| SatO2 (per percentage point) | 0.93 (0.92–0.95) | 0.01 | <0.001 | 0.97 (0.95–0.99) | 0.01 | 0.003 |
| CRP (per ng/ml) | 1.01 (1.01–1.01) | 0.00 | <0.001 | 1.01 (1.00–1.01) | 0.00 | <0.001 |
| Fibrinogen (per ng/ml) | 1.00 (1.00–1.00) | 0.00 | <0.001 | 1.00 (1.00–1.00) | 0.00 | 0.493 |
| Prothrombin act. (per ng/ml) | 0.97 (0.97–0.98) | 0.00 | <0.001 | 1.00 (0.99–1.00) | 0.00 | 0.288 |
| D-dimer (per ng/ml) | 1.00 (1.00–1.00) | 0.00 | <0.001 | 1.00 (1.00–1.00) | 0.00 | 0.258 |
| Hydroxychloroquine | 1.63 (0.72–3.67) | 0.68 | 0.240 | 2.72 (0.60–12.37) | 2.10 | 0.195 |
| Lopinavir/ritonavir | 1.76 (1.22–2.55) | 0.33 | 0.003 | 1.32 (0.80–2.18) | 0.34 | 0.279 |
| Azithromycin | 1.03 (0.75–1.40) | 0.16 | 0.868 | 0.79 (0.52–1.19) | 0.17 | 0.263 |
| Corticosteroids | 3.77 (2.81–5.06) | 0.56 | <0.001 | 1.53 (1.07–2.18) | 0.28 | 0.020 |
Abbreviatures: TIA: transient ischemic attack; CKD: chronic kidney disease; PAD: peripheral artery disease; COPD: chronic pulmonary obstructive disease; SBP: systolic blood pressure; CRP: C-reactive protein.