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. 2021 Mar;81:100883. doi: 10.1016/j.preteyeres.2020.100883

Fig. 2.

Fig. 2

Manhattan plot illustrating a genome wide significant association between Fuchsendothelialcornealdystrophy (FECD) and a region on chromosome 18, encompassing TCF4. Genome wide association study (GWAS) comparing 338,727 Single-Nucleotide Polymorphisms (SNPs) and FECD. The negative log of the P values of association between genotyped SNPs and an FECD discovery cohort is plotted against chromosomal location. One region on chromosome 18, encompassing TCF4, was found to reach genome wide significance (p = 1.0 × 10−12) within this discovery cohort. Used with permission from Baratz et al. (2010).