Table 1.

Patient Demographic and Clinicopathologic Characteristics in the JHH cohort

		All patients (n = 502)
Characteristics		No.	%
Demographics
Age, years	Median (IQR)	58.4 (49.8–66.4)
Sex	Male : Female	296 : 206	59.0 : 41.0
Primary CRC characteristics
Tumour site	Colon : Rectum	396 : 106	78.9 : 21.1
T stage (n=454)	T1or T2 stage : T3 or T4 stage	82 : 372	18.1 : 81.9
Nodal metastases	Negative:Positive	163 : 339	32.5 : 67.5
Preoperative factors
Disease-free interval	< 12 months : > 12 months	370 : 132	73.7 : 26.3
Chemotherapy for liver disease	Total : Combined cytotoxic regimen : Combined cytotoxic regime and biologic agent	335 : 306 : 201	66.7 : 91.3* : 60.0*
Preoperative CEA, ng/mL	Median (IQR)	7.6 (3.5–21.3)
Extrahepatic disease at the time of operation		50	10.0
Tumour factors
No. of CRLM	Median (IQR)	2.0 (1.0–4.0)
Size of largest CRLM, cm	Median (IQR)	2.6 (1.6–4.1)
Tumour Burden Score	Median (IQR)	4.1 (2.8–6.1)
Bilobar disease		214	42.6
KRAS mutation status	Wild-type : Mutated	320 : 182	63.7 : 36.3
Operative factors
Major resection		163	32.5
Resection margin, mm	Median (IQR)	5.0 (1.0–10.0)
R1		52	8.6
Postoperative factors
Postoperative chemotherapy (n=451)	Yes : No	321 : 130	71.2 : 28.8

CEA, carcinoembryonic antigen; CRC, colorectal cancer; CRLM, colorectal liver metastases; IQR, interquartile range; R1, resection margin exposure in pathology specimen

^*,proportion in total preoperative chemotherapy for liver disease