Table 3.
The effect of HNTX-III analogues to the release rate of β-hexosaminidase of RBL-2H3 cells
| ID | Analogues | Releasing rate of β-hexosaminidase (%) |
|---|---|---|
| - | Control | 1.13 ± 0.59 |
| 1 | HNTX-III | 1.68 ± 0.76 |
| 39 (H1) | K0G1-A21L-V | 1.63 ±0.96 |
| 40 (H2) | P18K-A21L-V | 2.06 ± 0.00 |
| 41 (H3) | K0G1-N19L-A21L-V | 1.16 ± 0.18 |
| 42 (H4) | K0G1-P18K-A21L-V | 2.66 ± 0.87 |
| 43 (H5) | K0G1-P18K-A21V-V | 2.06 ± 0.92 |
| 44 (H6) | K0G1-P18K-A21L-L | 3.16 ± 0.64 |
| 45 (H7) | K0G1-N19L-A21L-L | 0.90 ± 0.55 |
| 46 (H8) | K0K1-P18K-A21L-L | 1.46 ± 0.96 |
| 47 (H9) | K0K1-N19L-A21L-L | 1.89 ± 0.92 |
| 48 (H10) | K0L1-P18K-A21L-L | 1.37 ± 0.86 |
| - | C48/80 | 15.72 ± 1.12a |
Data are shown mean ± SD, n = 3 to 6.
a
P < 0.0001 versus Control, one-way ANOVA followed by Dunnett’s post hoc tests.