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. 2021 Feb 23;296:100453. doi: 10.1016/j.jbc.2021.100453

Figure 5.

Figure 5

Comparison of type I collagen melting temperature in different tissues from P3H3 null and LH1 null mice.A, the thermal stability of type I collagen from the skin, tendon, and bone from WT (blue) and null (red) mice was monitored by CD at 221 nm in 0.05 M acetic acid at 10 °C/h heating rate. The upper and lower panels display P3H3 and LH1 mouse lines, respectively. The number of biological replicates (independently prepared tissue samples) used to generate each curve are shown in the bracket next to tissue information with colors corresponding to the genotypes as described above. B, magnification of the curves in (A) demonstrating the thermal transition between 31 and 43 °C of skin type I collagen from P3H3 and LH1 null mice and their WT controls.