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. 2021 Mar 19;153(7):e202012743. doi: 10.1085/jgp.202012743

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© 2021 Coleman et al.

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Figure 2. — Increased MT acetylation slows contractile kinetics and modulates mechanosensitive ROS production. (A–C and E–G) Representative sarcomere length and velocity during contraction (A and E) treated with Tubacin (red) and respective controls (gray); measured fractional shortening (B and F) and contractile kinetics (C and G) from cardiomyocytes and FDB fibers, respectively. (D) Quantification of the change in ROS production in cardiac cells during 2-Hz stimulated contractions measured by the change in dihydrofluorescein fluorescence increase (n = 7; control, n = 30; Tubacin, n = 31). (H) Quantification of the change in ROS production during 2-Hz cyclic stretch in FDB fibers (n = 3; control, n = 16; Tubacin, n = 18). *, P < 0.05; ***, P < 0.001.